Suppressor of fused regulates Gli activity through a dual binding mechanism.

  title={Suppressor of fused regulates Gli activity through a dual binding mechanism.},
  author={Mark A. Merchant and Felix F. Vajdos and Mark H. Ultsch and Henry R. Maun and Ulrich Wendt and Jennifer Cannon and William T Desmarais and Robert A. Lazarus and Abraham M de Vos and Frederic J de Sauvage},
  journal={Molecular and cellular biology},
  volume={24 19},
The Hedgehog pathway drives proliferation and differentiation by activating the Gli/Ci family of zinc finger transcription factors. Gli/Ci proteins form Hedgehog signaling complexes with other signaling components, including the kinesin-like protein Costal-2, the serine-threonine kinase Fused, and Suppressor of Fused [Su(fu)]. In these complexes Gli/Ci proteins are regulated by cytoplasmic sequestration, phosphorylation, and proteolysis. Here we characterize structural and functional… CONTINUE READING

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