Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1β-mediated toxicity through inhibition of multiple nuclear factor-κB-regulated proapoptotic pathways

@article{Karlsen2004SuppressorOC,
  title={Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1β-mediated toxicity through inhibition of multiple nuclear factor-κB-regulated proapoptotic pathways},
  author={Allan Ertman Karlsen and Peter E Heding and Helle Frob\ose and Sif Groth R\onn and Mogens Kruh\offer and Torben F. \Orntoft and Martine I. Darville and Decio L. Eizirik and Flemming Pociot and J\orn Nerup and Thomas Mandrup-Poulsen and Nils Billestrup},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={1998-2011}
}
The proinflammatory cytokine IL-1β induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-κB (NF-κB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback regulator of IL-1β- and IFN-γ-mediated signalling in rat islets and beta… CONTINUE READING