Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury.

@article{Langdale2008SuppressorOC,
  title={Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury.},
  author={Lorrie A. Langdale and Vicki Hoagland and Whitney Benz and Kimberly J. Riehle and Jean S. Campbell and Denny H. Liggitt and Nelson Fausto},
  journal={Journal of hepatology},
  year={2008},
  volume={49 2},
  pages={198-206}
}
BACKGROUND/AIMS Preservation of function requires tight regulation of the cellular events initiated when hepatic ischemia is followed by reperfusion (IR). One important mechanism modulating the cytokine-directed response to injury is Suppressors of Cytokine Signaling. SOCS1 and SOCS3 ensure appropriate intensity and duration of cytokine signaling through negative feedback on JAK-STAT signaling. The contribution of SOCS1 and SOCS3-mediated regulation to the evolution of hepatic IR injury is… CONTINUE READING

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