Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

Abstract

Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5-deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COPD patients, again correlating with increased susceptibility to influenza. Importantly, restoration of SOCS5 levels restricted influenza virus infection, suggesting that manipulating SOCS5 expression and/or SOCS5 targets might be a novel therapeutic approach to influenza.

DOI: 10.7554/eLife.20444

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Cite this paper

@inproceedings{Kedzierski2017SuppressorOC, title={Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling}, author={Lukasz Kedzierski and Michelle D Tate and Alan C Hsu and Tatiana B Kolesnik and Edmond M Linossi and Laura Dagley and Zhaoguang Dong and Sarah Freeman and Giuseppe Infusini and Malcolm R Starkey and Nicola L Bird and Simon M Chatfield and Jeffrey J Babon and Nicholas Huntington and Gabrielle Belz and Andrew Webb and Peter Ab Wark and Nicos A Nicola and Jianqing Xu and Katherine Kedzierska and Philip M Hansbro and Sandra E Nicholson}, booktitle={eLife}, year={2017} }