Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.

@article{Cornish2003SuppressorOC,
  title={Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.},
  author={Ann L. Cornish and Mark M. W. Chong and Gayle M Davey and Rima Darwiche and Nicos A. Nicola and Douglas J. Hilton and Thomas W. H. Kay and Robyn Starr and Warren S. Alexander},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 25},
  pages={22755-61}
}
Suppressor of cytokine signaling-1 (SOCS-1) is an essential regulator of cytokine signaling. SOCS-1-/- mice die before weaning with a complex disease characterized by fatty degeneration and necrosis of the liver. This disease is mediated by interferon (IFN) gamma as neonatal mortality fails to occur in SOCS-1-/-IFNgamma-/- mice. However, the immune system of healthy SOCS-1-/-IFNgamma-/- mice is dysregulated with a reduced ratio of CD4:CD8 T cells and increases in some aspects of T cell… CONTINUE READING