Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis.

@article{Cornish2003SuppressorOC,
  title={Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis.},
  author={Ann L. Cornish and Gayle M Davey and Donald Metcalf and Jared F. Purton and Jason E. Corbin and Christopher J. Greenhalgh and Rima Darwiche and Li Wu and Nicos A. Nicola and Dale I Godfrey and William R Heath and Douglas J. Hilton and Warren S. Alexander and Robyn Starr},
  journal={Journal of immunology},
  year={2003},
  volume={170 2},
  pages={878-86}
}
Suppressor of cytokine signaling (SOCS)-1 is a member of a family of proteins that negatively regulate cytokine signaling pathways. We have previously established that SOCS-1 is a key regulator of IFN-gamma signaling and that IFN-gamma is responsible for the complex inflammatory disease that leads to the death of SOCS-1-deficient mice. In this study, we provide evidence that SOCS-1 is also a critical regulator of IFN-gamma-independent immunoregulatory factors. Mice lacking both SOCS-1 and IFN… CONTINUE READING
27 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…