Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.

@article{Dey2000SuppressorOC,
  title={Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.},
  author={Barna Dey and Richard W. Furlanetto and Peter Nissley},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={278 1},
  pages={38-43}
}
SOCS proteins are a class of proteins that are negative regulators of cytokine receptor signaling via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. In a yeast two-hybrid screen of a human fetal brain library, we have previously identified SOCS-2 as a binding partner of the activated IGF-I receptor (IGFIR). To test whether or not SOCS-3 also binds to the IGFIR, we cloned human SOCS-3 by reverse transcription-polymerase chain reaction from human skeletal… CONTINUE READING