Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells.

@article{Chen2015SuppressorOT,
  title={Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells.},
  author={Rui Yi Chen and Jing Zhu and Yong Gul Dong and Chao He and Xiaotong Hu},
  journal={Oncotarget},
  year={2015},
  volume={6 32},
  pages={
          32841-55
        }
}
The human telomerase reverse transcriptase (hTERT) promoter promotes differential hTERT gene expression in tumor cells and normal cells. However, information on the mechanisms underlying the differential hTERT transcription and induction of telomerase activity in tumor cells is limited. In the present study, suppressor of Ty homolog-5 (SPT5), a protein encoded by the SUPT5H gene, was identified as a novel tumor-specific hTERT promoter-binding protein and activator in colon cancer cells. We… CONTINUE READING
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