Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer Cells

Abstract

Suppressor of cytokine signaling (SOCS) family is an important negative regulator of cytokine signaling and deregulation of SOCS has been involved in many types of cancer. All cervical cancer cell lines tested showed lower expression of SOCS1, SOCS3, and SOCS5 than normal tissue or cell lines. The immunohistochemistry result for SOCS proteins in human… (More)
DOI: 10.1371/journal.pone.0123133

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@inproceedings{Kim2015SuppressorOC, title={Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer Cells}, author={Moon-Hong Kim and Moon-Sun Kim and Wonwoo Kim and Mi Ae Kang and Nicholas A. Cacalano and Soon-Beom Kang and Young-joo Shin and Jae-Hoon Jeong}, booktitle={PloS one}, year={2015} }