Suppressor cells and immunoregulation.

  title={Suppressor cells and immunoregulation.},
  author={M. E. Dorf and Baruj Benacerraf},
  journal={Annual review of immunology},
We have described a model system of immunoregulation in which gene products associated with both the major histocompatibility complex and the heavy-chain immunoglobulin gene complex guide a series of cellular interactions. The Igh genetic restrictions may represent the use of internal images of antigen and idiotype as suppressor-T cell receptors. The data indicate that the T-cell and B-cell Igh products are distinct. The T cell-derived idiotype-like determinants are used for suppressor-T cell… CONTINUE READING
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