Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis.

@article{Piek2001SuppressorAO,
  title={Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis.},
  author={Ester Piek and Anita B. Roberts},
  journal={Advances in cancer research},
  year={2001},
  volume={83},
  pages={1-54}
}
Transforming growth factor-beta (TGF-beta) has been implicated in oncogenesis since the time of its discovery almost 20 years ago. The complex, multifunctional activities of TGF-beta endow it with both tumor suppressor and tumor promoting activities, depending on the stage of carcinogenesis and the responsivity of the tumor cell. Dysregulation or alteration of TGF-beta signaling in tumorigenesis can occur at many different levels, including activation of the ligand, mutation or transcriptional… CONTINUE READING
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