Suppressive subtractive hybridization detects extensive genomic diversity in Thermotoga maritima.

Abstract

Comparisons between genomes of closely related bacteria often show large variations in gene content, even between strains of the same species. Such studies have focused mainly on pathogens; here, we examined Thermotoga maritima, a free-living hyperthermophilic bacterium, by using suppressive subtractive hybridization. The genome sequence of T. maritima MSB8… (More)

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Cite this paper

@article{Nesb2002SuppressiveSH, title={Suppressive subtractive hybridization detects extensive genomic diversity in Thermotoga maritima.}, author={Camilla L. Nesb\o and Karen E. Nelson and W. Ford Doolittle}, journal={Journal of bacteriology}, year={2002}, volume={184 16}, pages={4475-88} }