Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice.

@article{Dong2005SuppressiveOD,
  title={Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice.},
  author={Li Ming Dong and Shuichi Ito and Ken J Ishii and Dennis M Klinman},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 2},
  pages={651-8}
}
OBJECTIVE Synthetic oligodeoxynucleotides (ODN) expressing TTAGGG motifs suppress the production of proinflammatory cytokines and have been proven effective at blocking the development of certain organ-specific autoimmune diseases. We undertook this study to determine whether suppressive ODN alter the development of systemic autoimmunity, by evaluating… CONTINUE READING