Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses.

@article{Lin2008SuppressiveEA,
  title={Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses.},
  author={Yih-Jyh Lin and Hidetaka Hara and Hao-Chih Tai and Cassandra Long and Daisuke Tokita and Peter Yeh and David L. Ayares and Adrian E Morelli and David K C Cooper},
  journal={Transplantation},
  year={2008},
  volume={86 10},
  pages={1452-62}
}
BACKGROUND An understanding of the mechanisms that suppress the human anti-pig cellular response is key for xenotransplantation. We have compared the ability of human regulatory T cells (Tregs) to suppress xenogeneic and allogeneic responses in vitro. METHODS Human peripheral blood mononuclear cells (PBMC), CD4+ T cells, or CD4+ CD25- T cells were stimulated with irradiated human or wild type (WT) or alpha1,3-galactosyltransferase gene-knockout (GT-KO) pig PBMC in the presence or absence of… CONTINUE READING

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