Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice.

@article{Fukutake1998SuppressiveEO,
  title={Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice.},
  author={Masato Fukutake and Seiichi Nakatsugi and Takashi Isoi and Masakazu Takahashi and Toshihisa Ohta and Soichi Mamiya and Yayoi Taniguchi and Hidetaka Sato and Kenzou Fukuda and Takashi Sugimura and Keiji Wakabayashi},
  journal={Carcinogenesis},
  year={1998},
  volume={19 11},
  pages={1939-42}
}
The effects of nimesulide, a selective inhibitor of cyclooxygenase-2 (COX-2) on azoxymethane (AOM)-induced colon carcinogenesis were investigated in mice. AOM at a dose of 10 mg/kg body wt was administered to male ICR mice once a week for 6 weeks. The animals were fed on AIN-76A powder diet containing nimesulide at doses of 200 or 400 p.p.m., starting the… CONTINUE READING