Suppressive effects of interleukin-10 on human mononuclear phagocyte function against Candida albicans and Staphylococcus aureus.

@article{Roilides1998SuppressiveEO,
  title={Suppressive effects of interleukin-10 on human mononuclear phagocyte function against Candida albicans and Staphylococcus aureus.},
  author={Emmanuel Roilides and A Anastasiou-Katsiardani and A Dimitriadou-Georgiadou and Isaac Kadiltsoglou and S Tsaparidou and Christos P. Panteliadis and Thomas J Walsh},
  journal={The Journal of infectious diseases},
  year={1998},
  volume={178 6},
  pages={1734-42}
}
The effects of interleukin (IL)-10, a potent antiinflammatory cytokine, on human monocyte functions against two medically important pathogens, Candida albicans and Staphylococcus aureus, were studied. Incubation with 20-100 ng/mL IL-10 for 2-3 days decreased the fungicidal activity of monocytes against serum-opsonized C. albicans blastoconidia (P</=.04), reduced their capacity to damage unopsonized hyphae (P</=.006), and suppressed superoxide anion production in response to phorbol myristate… CONTINUE READING

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