Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice.

  title={Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice.},
  author={Tong-Rong Jan and S Su and Hsin-Ying Wu and Mei-Hsiu Liao},
  journal={International immunopharmacology},
  volume={7 6},
  • T. JanS. Su M. Liao
  • Published 1 June 2007
  • Biology, Medicine
  • International immunopharmacology

Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice

It is demonstrated that ANE modulated antigen-specific immune responses and promoted inflammatory reactions in vivo, which may contribute to immune deregulation associated with areca-related diseases.

Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice.

  • Fu-Hua KuoT. Jan
  • Biology, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2009

Cannabidiol (CBD) enhances lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice

The present studies demonstrate that oral administration of CBD enhanced lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice, and demonstrate that the CBD-mediated enhancement of LPS- induced pulmonary inflammation is mediated at the level of transcription of a variety of pro-inflammatory genes.

Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity

CBD curbs DTH reactions via suppressing the infiltration and functional activity of T cells and macrophages in the inflammatory site, suggesting a therapeutic potential for CBD for the treatment of type IV hypersensitivity.

A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis

Daily treatment with topical 1 % CBD-cream may exert neuroprotective effects against EAE, diminishing clinical disease score, and suggest an interesting new profile of CBD that could lead to its introduction in the clinical management of MS and its associated symptoms at least in association with current conventional therapy.

Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood

The anti-inflammatory and immuno-modulating properties of CBD are demonstrated for the first time directly in dogs’ immune cells, using a canine ex vivo inflammatory model.

Cannabidiol: Influence on B Cells, Peripheral Blood Mononuclear Cells, and Peripheral Blood Mononuclear Cell/Rheumatoid Arthritis Synovial Fibroblast Cocultures.

CBD is able to provide pro- and anti-inflammatory effects in isolated B cells and PBMCs, which might be used to dampen B cell activity in autoimmune conditions such as rheumatoid arthritis.



delta1-tetrahydrocannabinol, cannabidiol and cannabinol effects on the immune response of mice.

Production of humoral immunity was specific for THC but not for cannabidiol at 25 mg/kg or cannabinol at 25mg/kg, and suppression of the antigenic response by THC was reflected as a reduction ofsplenic weight, reduction in the number of splenic antibody-forming cells, lowered hemagglutination titer and reduction inThe percentage of splenetic white pulp of total spleen volume.

Effects of delta 9-tetrahydrocannabinol, cannabinol and cannabidiol on the immune system in mice. II. In vitro investigation using cultured mouse splenocytes.

Treatment of splenocyte cultures with cannabinoids after the first 24 h after antigenic stimulation showed no impairment of the in vitro primary-like immune response.

Effects of Δ9-Tetrahydrocannabinol, Cannabinol and Cannabidiol on the Immune System in Mice

The effects of the cannabinoids Δ9-tetrahydrocannabinol (THC), cannabinol and cannabidiol and the memory aspect of humoral immunity in response to sheep red blood cell immunization was investigated and in vivo investigations of the effects of cannabinoids on the thymus were carried out.

A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.

The studies show that the novel synthetic cannabinoid acid HU-320 has strong antiinflammatory and immunosuppressive properties while demonstrating no psychoactive effects, which indicate its usefulness as a novel nonpsychoactive, synthetic antiinflammatory product.

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

Data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA.