Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins.

  title={Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins.},
  author={Albert Amberger and M H{\'a}la and Maria Saurwein-Teissl and Bernhard Metzler and Beatrix Grubeck-Loebenstein and Qingbo Xu and George Wick},
  journal={Molecular medicine},
  volume={5 2},
BACKGROUND Studies from our laboratory have shown that the earliest stages of atherosclerosis may be mediated by an autoimmune reaction against heat shock protein 60 (Hsp60). The interactions of Hsp60-specific T cells with arterial endothelial cells (EC) require expression of both Hsp60 and certain adhesion molecules shown to be induced simultaneously in EC by mechanical and other types of stress. Recently, it was shown that suppression of T cell-mediated immune responses by cyclosporin A (CyA… CONTINUE READING


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