Suppressive effects of T-412, a flavone on interleukin-4 production in T cells.

@article{Jin2009SuppressiveEO,
  title={Suppressive effects of T-412, a flavone on interleukin-4 production in T cells.},
  author={Mirim Jin and Sunyoung Park and Myoung-yun Pyo},
  journal={Biological \& pharmaceutical bulletin},
  year={2009},
  volume={32 11},
  pages={
          1875-9
        }
}
Interleukin (IL)-4 has been suggested as a molecular therapeutic target to prevent and/or treat various allergic diseases and several flavonoids have been suggested as anti-allergic agents suppressing IL-4 production. In an effort to find novel candidates for anti-allergic agents from natural sources, we screened several flavonoids affecting on IL-4 production. In this study, we showed that 7,8,4'-trihydroxyflavone (T-412) significantly decreased IL-4 production both in phorbol 12-myristate 13… 
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