Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.

@article{Oh2006SuppressiveEO,
  title={Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.},
  author={Sei-Ryang Oh and Mee Young Lee and Kyungseop Ahn and B C Park and Ok-Kyuoung Kwon and Hyouk Joung and Joongku Lee and Doo-young Kim and Sangku Lee and Joo Heon Kim and Hyeong-Kyu Lee},
  journal={International immunopharmacology},
  year={2006},
  volume={6 6},
  pages={
          978-86
        }
}
Allergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters--such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion--in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL… CONTINUE READING

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