• Corpus ID: 9680060

Suppressive effect of clenbuterol on citric acid-induced cough reflex in guinea pigs.

@article{Horiuchi1995SuppressiveEO,
  title={Suppressive effect of clenbuterol on citric acid-induced cough reflex in guinea pigs.},
  author={Hideki Horiuchi and Takashi Nonaka and M. It{\^o} and Takahiro Kaniwa and Tadashi Kishimoto and Jun-ichi Fuchikami and Yoshiro Kohjimoto and Mamoru Kiyoki},
  journal={Research communications in molecular pathology and pharmacology},
  year={1995},
  volume={88 3},
  pages={
          293-301
        }
}
  • H. Horiuchi, T. Nonaka, +5 authors M. Kiyoki
  • Published 1 June 1995
  • Biology, Medicine
  • Research communications in molecular pathology and pharmacology
We previously demonstrated that clenbuterol suppressed bronchial hyperresponsiveness in acute bronchitic models. However the effect of clenbuterol on the cough reflex, the main symptom of acute bronchitis, is not clear. The present study was thus undertaken to investigate the influence of clenbuterol on the cough reflex. Oral administration of clenbuterol (3 and 10 micrograms/kg) to guinea pigs markedly inhibited the increase in the respiratory resistance in response to 5-HT in a dose-dependent… 
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