Suppressive effect of Saiko-ka-ryukotsu-borei-to, a herbal medicine, on excessive release of glutamate in the hippocampus.

Glutamate is the major excitatory neurotransmitter in the brain, and the excess of glutamate concentration in the synaptic cleft is a cause of neuronal injury or death. To find out a drug suppressing the excess of extracellular glutamate concentration, the effect of Saiko-ka-ryukotsu-borei-to, a herbal medicine, was examined in the control and zinc… (More)