Suppressive activity of a macrolide antibiotic, roxithromycin, on pro-inflammatory cytokine production in vitro and in vivo.

@article{Suzaki1999SuppressiveAO,
  title={Suppressive activity of a macrolide antibiotic, roxithromycin, on pro-inflammatory cytokine production in vitro and in vivo.},
  author={Harumi Suzaki and Kazuhito Asano and Shinji Ohki and Ken-ichi Kanai and Tetsu Mizutani and Tadashi Hisamitsu},
  journal={Mediators of Inflammation},
  year={1999},
  volume={8},
  pages={199 - 204}
}
This study was designed to examine the influence of a macrolide antibiotic, roxithromycin (RXM), on the production of pro-inflammatory cytokines, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha. In the first experiments, we examined the effect of RXM on in vitro cytokine production from lipopolysaccharide (LPS)-stimulated human peripheral blood monocytes. The monocytes were cultured in the presence of various doses of the agent. After 24 h, the culture supernatants were obtained… CONTINUE READING