Suppressive action of resolvin D1 on the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice.

@article{Murakami2011SuppressiveAO,
  title={Suppressive action of resolvin D1 on the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice.},
  author={Taisuke Murakami and Kaori Suzuki and Hiroshi Tamura and Isao Nagaoka},
  journal={Experimental and therapeutic medicine},
  year={2011},
  volume={2 1},
  pages={
          57-61
        }
}
Endotoxin/septic shock is a severe condition induced during serious infections with Gram-negative bacteria. To evaluate the therapeutic potential of resolvin D1 (RvD1), a novel pro-resolving molecule, on endotoxin/septic shock, we investigated the effect of RvD1 on the extracellular release of high mobility group box-1 (HMGB1), the production of inflammatory cytokines, the accumulation of peritoneal cells and hepatocyte apoptosis in vivo using a D-galactosamine (GalN)-sensitized mouse endotoxin… 

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