Suppressive Role of Indole on 2-Acetylaminofluorene Hepatotoxicity

  title={Suppressive Role of Indole on 2-Acetylaminofluorene Hepatotoxicity},
  author={Martin Hopp and Mami Matsumoto and B Wendell and Chien-Nan Lee and Ryoichi Oyasu},
  journal={Cancer research},
  volume={36 1},
Indole is known to suppress the hepatotoxicity and carcinogenicity of 2-acetylaminofluorene (AAF) in rats and hamsters. For elucidation of the mechanism of its protective role, 2 experiments were conducted using young male rats. In the 1st experiment, the 24-hr biliary excretion of N-hydroxy-2-acetylaminofluorene (N-OH-AAF)-glucuronide was measured after 2 and 4 weeks of dietary administration of 0.03% AAF with or without 1.6% indole. The amount of [9-14C]N-OH-AAF that was excreted as the… CONTINUE READING


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Conjugates of N-Hydroxy Compounds

C. C. Irving
pp. 53— 119.New York: Academic Press,Inc.,1970 • 1970
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