Suppressive Effects of Vascular Endothelial Growth Factor-B on Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis

@inproceedings{Albrecht2010SuppressiveEO,
  title={Suppressive Effects of Vascular Endothelial Growth Factor-B on Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis},
  author={Imke Albrecht and Lucie Kopfstein and Karin Strittmatter and Tibor Schomber and Annelie Falkevall and Carolina E. Hagberg and Pascal Lorentz and Michael Jeltsch and Kari Alitalo and Ulf Eriksson and Gerhard Christofori and Kristian Pietras},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The family of vascular endothelial growth factors (VEGF) contains key regulators of blood and lymph vessel development, including VEGF-A, -B, -C, -D, and placental growth factor. The role of VEGF-B during physiological or pathological angiogenesis has not yet been conclusively delineated. Herein, we investigate the function of VEGF-B by the generation of mouse models of cancer with transgenic expression of VEGF-B or homozygous deletion of Vegfb. METHODOLOGY/PRINCIPAL FINDINGS… CONTINUE READING