Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model

@inproceedings{Park2012SuppressiveEO,
  title={Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model},
  author={Mi Ra Park and Ji Hee Lee and Myung Suk Park and Jun Eul Hwang and Hyun-Jeong Shim and Sang Hee Cho and I J Chung and Woo Kyun Bae},
  booktitle={Journal of Korean medical science},
  year={2012}
}

• Mi Ra Park, Ji Hee Lee, +5 authors Woo Kyun Bae
• Published 2012 in Journal of Korean medical science
• DOI:10.3346/jkms.2012.27.9.1037

The active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) (calcitriol), inhibits the growth of several types of human cancer cells in vitro, but its therapeutic use is limited because it causes hypercalcemia. Among its analogs, 19-nor-1,25-dihydroxyvitamin D(2) (paricalcitol), has fewer calcemic effects and exhibits an activity equipotent to that of calcitriol. We assessed the antitumor and anti-inflammatory effects of paricalcitol in gastric cancer cells, and evaluated the potential role… CONTINUE READING

Save to Library

Create Alert

Cite

View Paper