Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model

@inproceedings{Park2012SuppressiveEO,
  title={Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model},
  author={Mi Ra Park and Ji Hee Lee and Myung Suk Park and Jun Eul Hwang and Hyun-Jeong Shim and Sang Hee Cho and I J Chung and Woo Kyun Bae},
  booktitle={Journal of Korean medical science},
  year={2012}
}
The active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) (calcitriol), inhibits the growth of several types of human cancer cells in vitro, but its therapeutic use is limited because it causes hypercalcemia. Among its analogs, 19-nor-1,25-dihydroxyvitamin D(2) (paricalcitol), has fewer calcemic effects and exhibits an activity equipotent to that of calcitriol. We assessed the antitumor and anti-inflammatory effects of paricalcitol in gastric cancer cells, and evaluated the potential role… CONTINUE READING
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