Suppressive CD8+ T cells arise in the absence of CD4 help and compromise control of persistent virus.

@article{Molloy2011SuppressiveCT,
  title={Suppressive CD8+ T cells arise in the absence of CD4 help and compromise control of persistent virus.},
  author={Michael J. Molloy and Weijun Zhang and Edward J. Usherwood},
  journal={Journal of immunology},
  year={2011},
  volume={186 11},
  pages={6218-26}
}
There is an urgent need to develop novel therapies for controlling chronic virus infections in immunocompromised patients. Disease associated with persistent γ-herpesvirus infection (EBV, human herpesvirus 8) is a significant problem in AIDS patients and transplant recipients, and clinical management of these conditions is difficult. Immune surveillance failure followed by γ-herpesvirus recrudescence can be modeled using murine γ-herpesvirus (MHV)-68 in mice lacking CD4(+) T cells. In contrast… CONTINUE READING
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