Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells.

@article{Murphy1999SuppressionSH,
  title={Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells.},
  author={Margaret Ann Murphy and Catherine Godson and Stephen Cannon and Shigeaki Kato and Harald S Mackenzie and Finian M Martin and Hugh R. Brady},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 9},
  pages={5830-4}
}
Accumulation of mesangial matrix is a pivotal event in the pathophysiology of diabetic nephropathy. The molecular triggers for matrix production are still being defined. Here, suppression subtractive hybridization identified 15 genes differentially induced when primary human mesangial cells are exposed to high glucose (30 mM versus 5 mM) in vitro. These genes included (a) known regulators of mesangial cell activation in diabetic nephropathy (fibronectin, caldesmon, thrombospondin, and… CONTINUE READING

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CTGF Expression in Human Mesangial Cells

Mackenzie, Finian Martin, +4 authors S Harald
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