Suppression of visual cortical evoked responses following deprivation of pattern vision in adult mice

@article{Siu2008SuppressionOV,
  title={Suppression of visual cortical evoked responses following deprivation of pattern vision in adult mice},
  author={Timothy L T Siu and John W. Morley},
  journal={European Journal of Neuroscience},
  year={2008},
  volume={28}
}
  • T. Siu, J. Morley
  • Published 1 August 2008
  • Biology, Psychology
  • European Journal of Neuroscience
The effect of visual loss on the adult neocortex can have significant impact on the success of a visual implant. Recent research has shown that the adult neocortex retains substantial plasticity following a disruption to its afferent input. The result of these changes may hamper the development of a visual prosthesis if visual sensation cannot be effectively restored by stimulation of the surviving elements of the visual pathway. In order to evaluate further the visual performance of the… 

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References

SHOWING 1-10 OF 61 REFERENCES

Visual cortical potentials of the mouse evoked by electrical stimulation of the retina

Deficits in the visual evoked potentials of cats as a result of visual deprivation

TLDR
The use of visual evoked potentials in response to contrast reversal of grating patterns were used as a measure of visual function in normal and visually deprived cats and reinforces the idea that two factors govern cortical development: competition and experience.

Changes in visual cortex excitability in blind subjects as demonstrated by transcranial magnetic stimulation.

TLDR
In blind subjects there is alteration in TMS-induced activation of the deafferented visual cortex or processes engaged in bringing the artificial cortex input to consciousness, and the ability to elicit phosphenes is reduced in subjects with a high degree of visual de Afferentation.

Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF

TLDR
In dark-reared transgenic mice, visual acuity, receptive field size of visual cortical neurons, critical period for ocular dominance plasticity, and intracortical inhibition were indistinguishable from those observed in light- reared mice, suggesting that BDNF overexpression is sufficient for the development of aspects of visual cortex in the absence of visual experience.

Human Adult Cortical Reorganization and Consequent Visual Distortion

TLDR
Together, the behavioral and fMRI data show that loss of input to V1 after a stroke leads to cortical reorganization in the adult human visual system, and provide the first evidence that reorganization of the adult visual system affects visual perception.

Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex

TLDR
The data demonstrate that the experience-dependent modifications observed in the adult visual cortex are different from those observed during development, and these differences may help to explain the unique consequences of sensory deprivation on plasticity in the developing versus mature cortex.

Visual perception elicited by electrical stimulation of retina in blind humans.

TLDR
Evaluating the feasibility of bypassing damaged photoreceptors and electrically stimulating the remaining viable retinal layers to provide limited visual input to patients who are blind because of severe photoreceptor degeneration results in focal light perception that seems to arise from the stimulated area.
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