Suppression of ventricular ectopic depolarizations by flecainide acetate, a new antiarrhythmic agent.

@article{Hodges1982SuppressionOV,
  title={Suppression of ventricular ectopic depolarizations by flecainide acetate, a new antiarrhythmic agent.},
  author={Mary Hodges and J M Haugland and G A Granrud and G. J. Conard and Richard W. Asinger and Frank L Mikell and Jan Krejci},
  journal={Circulation},
  year={1982},
  volume={65 5},
  pages={879-85}
}
Flecainide acetate, a new antiarrhythmic agent, was given orally to 11 hospitalized patients with chronic high-frequency ventricular ectopic depolarizations. Drug effectiveness was evaluated with a dose-ranging single-blind protocol, which included placebo control and washout periods. Twice-daily dosing (average daily dose 436 mg) completely suppressed all ventricular ectopic activity in five of 11 patients; average suppression in the 11 patients was 96.3%. Complex ventricular arrhythmias… CONTINUE READING

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