Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis.

@article{Clifford2002SuppressionOT,
  title={Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis.},
  author={John L. Clifford and Eugene Walch and Xiulan Q Yang and Xiaochun Xu and David S. Alberts and Gary L Clayman and A El-naggar and Reuben Lotan and Scott Michael Lippman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 7},
  pages={2067-72}
}
PURPOSE IFN-based therapy has been shown to be active in the treatmentof squamous cell carcinoma (SCC) of the skin, the most aggressive form of non-melanoma skin cancer. Based largely on this activity, we began programmatically examining the expression of IFN-stimulated gene factor 3 (ISGF-3) proteins (signal transducers and activators of transcription 1alpha/beta, signal transducers and activators of transcription 2, and p48), which are important mediators of IFN-alpha signaling, in skin… CONTINUE READING
17 Citations
21 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Retinoids and interferons: combination studies in human cancer

  • R. Lotan, J. L. Clifford, S. M. Lippman
  • Birkhauser Verlag,
  • 2000

Similar Papers

Loading similar papers…