Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

@article{Bookstein1990SuppressionOT,
  title={Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.},
  author={Robert Bookstein and J. Y. Shew and Peter C. Y. Chen and Paul Scully and Won Hyuck Lee},
  journal={Science},
  year={1990},
  volume={247 4943},
  pages={712-5}
}
Introduction of a normal retinoblastoma gene (RB) into retinoblastoma cells was previously shown to suppress several aspects of their neoplastic phenotype, including tumorigenicity in nude mice, thereby directly demonstrating a cancer suppression function of RB. To explore the possibility of a similar activity in a common adult tumor, RB expression was examined in three human prostate carcinoma cell lines. One of these, DU145, contained an abnormally small protein translated from an RB… CONTINUE READING

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