Suppression of tumorigenicity of human lung carcinoma cells after transfection with connexin43.

@article{Zhang1998SuppressionOT,
  title={Suppression of tumorigenicity of human lung carcinoma cells after transfection with connexin43.},
  author={Zhi-wei Zhang and Wenjun Zhang and Ning Qian Wang and Mahmud Bani-Yaghoub and Zhaojiang Lin and Christian C Naus},
  journal={Carcinogenesis},
  year={1998},
  volume={19 11},
  pages={
          1889-94
        }
}
The human lung carcinoma cell line PG is defective in gap junctional intercellular communication (GJIC). Connexin43 (Cx43) mRNA, which is expressed in normal human lung cells, is undetectable in these tumor cells. To explore if up-regulation of Cx43 gene expression will suppress malignancy of PG cells, Cx43 cDNA was co-transfected with pSV2neo cDNA into PG cells. Control cells were transfected with the blank vector plus neo cDNA. Several stable Cx43 transfectant clones, which acquired high… CONTINUE READING
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