Suppression of tumorigenicity of breast cancer cells by microcell-mediated chromosome transfer: studies on chromosomes 6 and 11.

@article{Negrini1994SuppressionOT,
  title={Suppression of tumorigenicity of breast cancer cells by microcell-mediated chromosome transfer: studies on chromosomes 6 and 11.},
  author={Massimo Negrini and Silvia Sabbioni and Laura Possati and Shashi Rattan and Alfredo Corallini and Giuseppe Barbanti-Brodano and Carlo M. Croce},
  journal={Cancer research},
  year={1994},
  volume={54 5},
  pages={1331-6}
}
Development of breast cancer has been associated with deletions at multiple chromosomal regions, including 6q, 11p, and 11q. In this study we analyzed the effects of the introduction of chromosomes 6 and 11 on the cell phenotype of the breast cancer cell lines MDA-MB-231 and MCF-7. Chromosome 6 induced alterations of in vitro growth properties and suppressed tumorigenicity of MDA-MB-231 cells. Spontaneous reduction of the transferred chromosome allowed mapping of the tumor suppressor gene(s) to… CONTINUE READING

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