Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer.

@article{Satoh1993SuppressionOT,
  title={Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer.},
  author={Hitoshi Satoh and Patricia W. Lamb and J. T. Dong and Jeff Everitt and C J Boreiko and Mitsuo Oshimura and Jeffrey C. Barrett},
  journal={Molecular carcinogenesis},
  year={1993},
  volume={7 3},
  pages={157-64}
}
To map tumor suppressor genes for lung adenocarcinomas, we introduced normal human chromosomes 3, 7, and 11 into the A549 tumor cell line by microcell-mediated chromosome transfer to test which chromosomes had the ability to suppress tumorigenicity. These human chromosomes, which contain the neomycin gene as a selectable marker, were transferred into A549 lung adenocarcinoma cells at frequencies of 0.3-1.8 x 10(-6). Two microcell hybrid clones with an introduced chromosome 3, two with an… CONTINUE READING

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