Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18

@article{Tanaka1991SuppressionOT,
  title={Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18},
  author={Kiyoko Tanaka and Mitsuo Oshimura and Rei Kikuchi and Madoka Seki and Takako Hayashi and Michiko Miyaki},
  journal={Nature},
  year={1991},
  volume={349},
  pages={340-342}
}
DEVELOPMENT of colon carcinomas can be associated with allelic deletions on several chromosomes, including 5q and 18q (refs 1–10). The APC gene11–13 on 5q and the DCC gene14 on 18q have been identified as potential tumour suppressor genes, whose suppression contributes to colon carcinogenesis. To investigate the role of genes in these deleted regions, we have now introduced a single normal human chromosome into a human colon carcinoma cell line, COKFu, through microcell hybridization15–20… CONTINUE READING