Suppression of tumorigenicity by plakoglobin: an augmenting effect of N- cadherin

@article{Simcha1996SuppressionOT,
  title={Suppression of tumorigenicity by plakoglobin: an augmenting effect of N- cadherin},
  author={Inbal Simcha and Benjamin Geiger and S Yehuda-Levenberg and Daniela Salomon and Avri Ben-Ze'ev},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={133},
  pages={199 - 209}
}
Plakoglobin is a major component of the submembranal plaque of adherens junctions and desmosomes in mammalian cells. It is closely related to the Drosophila segment polarity gene armadillo which has a role in the transduction of transmembrane signals that regulate cell fate. Like its close homologue beta-catenin, plakoglobin can associate with the product of the tumor suppressor gene APC that is linked to human colon cancer. We have studied the effect of plakoglobin overexpression, and the… CONTINUE READING