Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of nuclear factor kappaB: a possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjögren's syndrome patients.

Abstract

OBJECTIVE Our previous results suggested that suppression of tumor necrosis factor alpha (TNFalpha)-induced matrix metalloproteinase 9 (MMP-9) could prevent the destruction of acinar tissue in the salivary glands of patients with Sjögren's syndrome (SS). The present study was undertaken to investigate the effect of cepharanthine on the suppression of… (More)

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@article{Azuma2002SuppressionOT, title={Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of nuclear factor kappaB: a possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sj{\"{o}gren's syndrome patients.}, author={M Azuma and Keiko Aota and Tetsuya Tamatani and Katsumi Motegi and Tsuyoshi Yamashita and Yuki Ashida and Yoshio Hayashi and Mitsunobu Sato}, journal={Arthritis and rheumatism}, year={2002}, volume={46 6}, pages={1585-94} }