Suppression of tumor growth in lung cancer xenograft model mice by poly(sorbitol-co-PEI)-mediated delivery of osteopontin siRNA.

@article{Cho2015SuppressionOT,
  title={Suppression of tumor growth in lung cancer xenograft model mice by poly(sorbitol-co-PEI)-mediated delivery of osteopontin siRNA.},
  author={Won-Young Cho and Seong-Ho Hong and Bijay Singh and Mohammad Ariful Islam and Somin Lee and Ah Young Lee and Nomundelger Gankhuyag and J I Kim and K Yu and Kwang-Ho Kim and Young-Chan Park and Chong-su Cho and M. -Il Cho},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2015},
  volume={94},
  pages={450-62}
}
Small interfering RNA (siRNA)-mediated gene silencing represents a promising strategy for treating diseases such as cancer; however, specific gene silencing requires an effective delivery system to overcome the instability and low transfection efficiency of siRNAs. To address this issue, a polysorbitol-based transporter (PSOT) was prepared by low molecular… CONTINUE READING