Suppression of tumor growth by viral vector-mediated gene transfer of N-terminal truncated platelet factor 4.

@article{Li2003SuppressionOT,
  title={Suppression of tumor growth by viral vector-mediated gene transfer of N-terminal truncated platelet factor 4.},
  author={Yanhan Li and Yixin Jin and Huishu Chen and Gu Jie and G{\'e}rard Tobelem and Jacques Philippe Caen and Zhong Han},
  journal={Cancer biotherapy & radiopharmaceuticals},
  year={2003},
  volume={18 5},
  pages={
          829-40
        }
}
Platelet factor four (PF4), an inhibitor of endothelial cell proliferation in vitro, inhibits angiogenesis and tumor growth in vivo in experimental animals. The present study was designed to determine whether gene therapy-mediated expression of a form of PF4 lacking 16 amino acids of N-terminus from tumor cells could inhibit angiogenesis and tumor growth in vivo. Two replication-defective recombinant retroviral vectors were constructed. One encodes human PF4 (rRV-PF4) and the other encodes the… CONTINUE READING
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