Suppression of tumor growth and metastasis in Mgat5-deficient mice

Abstract

Golgi β1,6N-acetylglucosaminyltransferase V (MGAT5) is required in the biosynthesis of β1,6GlcNAc-branched N-linked glycans attached to cell surface and secreted glycoproteins. Amounts of MGAT5 glycan products are commonly increased in malignancies, and correlate with disease progression. To study the functions of these N-glycans in development and disease… (More)
DOI: 10.1038/73163

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@article{Granovsky2000SuppressionOT, title={Suppression of tumor growth and metastasis in Mgat5-deficient mice}, author={Maria Granovsky and Jimmie Fata and Judy Pawling and William J. Muller and Rama Khokha and J. W. Dennis}, journal={Nature Medicine}, year={2000}, volume={6}, pages={306-312} }