Suppression of tissue inhibitor of metalloproteinase-1 by recombinant adeno-associated viruses carrying siRNAs in hepatic stellate cells.

Abstract

Elevated tissue inhibitor of metalloproteinase (TIMP)-1 expression contributes to excess production of extracellular matrix in liver fibrosis. However, there are few studies on sustained suppression of TIMP-1. We aimed to construct a recombinant adeno-associated virus (AAV) carrying small interfering RNAs (siRNAs) of TIMP-1 and investigate the long-term… (More)

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@article{Cong2009SuppressionOT, title={Suppression of tissue inhibitor of metalloproteinase-1 by recombinant adeno-associated viruses carrying siRNAs in hepatic stellate cells.}, author={Min Cong and Tianhui Liu and Ping Wang and Yong Xu and Shuzhen Tang and Baoen Wang and Jidong Jia and Yong Liu and Paul L. Hermonat and Hong You}, journal={International journal of molecular medicine}, year={2009}, volume={24 5}, pages={685-92} }