Suppression of thrombospondin 1 and 2 production by herpes simplex virus 1 infection in cultured keratocytes.

@article{Choudhary2005SuppressionOT,
  title={Suppression of thrombospondin 1 and 2 production by herpes simplex virus 1 infection in cultured keratocytes.},
  author={Anshoo Choudhary and Paul Hiscott and Charles A. Hart and Stephen Bruce Kaye and Mark Batterbury and I. O. Grierson},
  journal={Molecular vision},
  year={2005},
  volume={11},
  pages={163-8}
}
PURPOSE Stromal vascularization is a frequent occurrence in herpes simplex keratitis (HSK) and carries a poor prognosis for penetrating keratoplasty. The pathogenesis may involve disruption of the normal equilibrium between angiogenic and anti-angiogenic factors in and around the cornea. Thrombospondin (TSP) 1 and 2 are multifunctional matricellular glycoproteins with potent anti-angiogenic properties and are expressed by human keratocytes in a stromal wound repair model. We hypothesize that… CONTINUE READING
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