Suppression of the rat micturition reflex by imipramine.

  title={Suppression of the rat micturition reflex by imipramine.},
  author={Uy Dong Sohn and Chae Young Kim},
  journal={Journal of autonomic pharmacology},
  volume={17 1},
1. This study investigates possible mechanisms through which imipramine (IMI) exerts its antienuretic effect. The micturition reflex in response to bladder distension produced by saline infusion was examined in anaesthetized rats. 2. The amplitude and frequency of micturition reflex contractions were reduced by peripheral administration of IMI, but the micturition reflex was abolished after its intracerebroventricular (i.c.v.) administration. A muscarinic antagonist, atropine, displayed an… CONTINUE READING