Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.

@article{Shiwaku2010SuppressionOT,
  title={Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.},
  author={Hiroki Shiwaku and Noriko Yoshimura and Takuya Tamura and Masaki Sone and Soichi Ogishima and Kei Watase and Kazuhiko Tagawa and Hitoshi Okazawa},
  journal={The EMBO journal},
  year={2010},
  volume={29 14},
  pages={
          2446-60
        }
}
Non-cell-autonomous effect of mutant proteins expressed in glia has been implicated in several neurodegenerative disorders, whereas molecules mediating the toxicity are currently not known. We identified a novel molecule named multiple alpha-helix protein located at ER (Maxer) downregulated by mutant ataxin-1 (Atx1) in Bergmann glia. Maxer is an endoplasmic reticulum (ER) membrane protein interacting with CDK5RAP3. Maxer anchors CDK5RAP3 to the ER and inhibits its function of Cyclin D1… CONTINUE READING
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