Suppression of the interferon and NF-κB responses by severe fever with thrombocytopenia syndrome virus.

@article{Qu2012SuppressionOT,
  title={Suppression of the interferon and NF-κB responses by severe fever with thrombocytopenia syndrome virus.},
  author={Bingqian Qu and Xian Qi and Xiaodong Wu and Mifang Liang and Chuan Li and Carol J. Cardona and Wayne Xu and Fenyang Tang and Zhifeng Li and B Wu and Kira Powell and Marta Wegner and De-xin Li and Zheng Xing},
  journal={Journal of virology},
  year={2012},
  volume={86 16},
  pages={8388-401}
}
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease characterized by high fever, thrombocytopenia, multiorgan dysfunction, and a high fatality rate between 12 and 30%. It is caused by SFTS virus (SFTSV), a novel Phlebovirus in family Bunyaviridae. Although the viral pathogenesis remains largely unknown, hemopoietic cells appear to be targeted by the virus. In this study we report that human monocytes were susceptible to SFTSV, which replicated efficiently, as… CONTINUE READING