Suppression of the immune response to FVIII in hemophilia A mice by transgene modified tolerogenic dendritic cells.

@article{Su2011SuppressionOT,
  title={Suppression of the immune response to FVIII in hemophilia A mice by transgene modified tolerogenic dendritic cells.},
  author={Rui-Jun Su and Angela Epp and Junli Feng and Jackie Roy and Yvette Latchman and Xiaoping Wu and D. C. Bolgiano and Neil C. Josephson},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2011},
  volume={19 10},
  pages={1896-904}
}
Current methods for eradicating clinically significant inhibitory antibodies to human factor VIII (hFVIII) in patients with hemophilia A rely on repeated delivery of high doses of factor concentrates for a minimum of many months. We hypothesize that tolerance can be induced more efficiently and reliably through hFVIII antigen presentation by tolerogenic dendritic cells (tDCs). In this study, we generated tDCs from hemophilia A mice and modified them with a foamy virus vector expressing a… CONTINUE READING
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