Suppression of the growth hormone (GH) response to clonidine and GH-releasing hormone by exogenous GH.

@article{Nakamoto1986SuppressionOT,
  title={Suppression of the growth hormone (GH) response to clonidine and GH-releasing hormone by exogenous GH.},
  author={Jon M. Nakamoto and Joseph M. Gertner and Charles Mcl. Press and Raymond L. Hintz and Ron G. Rosenfeld and Myron Genel},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1986},
  volume={62 5},
  pages={822-6}
}
GH release in response to clonidine and human GH-releasing hormone-(1-44) (hGHRH-44) was assessed in 11 boys (aged 7-14 yr) with short stature, who had normal GH secretion. The response to these 2 provocative stimuli was repeated after, respectively, 2 and 3 days of treatment with human GH (0.1 U/kg, im). Exogenous GH significantly blunted the response to both clonidine [the mean 2-h integrated serum GH concentration falling from 1050 +/- 350 (+/- SEM) to 749 +/- 297 ng/ml X min; P = 0.03] and… CONTINUE READING