Suppression of the cutaneous immune response following topical application of the prostaglandin PGE2.

@article{Rheins1987SuppressionOT,
  title={Suppression of the cutaneous immune response following topical application of the prostaglandin PGE2.},
  author={Lawrence A. Rheins and Lachlan M. Barnes and Somnuk Amornsiripanitch and Christine E. Collins and James J. Nordlund},
  journal={Cellular immunology},
  year={1987},
  volume={106 1},
  pages={
          33-42
        }
}
UVB irradiation (290-320 nm) and topical applications of arachidonic acid (AA) in mice decrease the number of identifiable Langerhans cells and alter the cutaneous immune response. Application of contact allergens such as dinitrofluorobenzene (DNFB) to irradiated or AA-treated skin induces antigen-specific tolerance. Indomethacin (IM), a cyclooxygenase inhibitor, administered orally to mice prior to UVB irradiation or prior to the topical application of arachidonic acid, abrogates suppression… CONTINUE READING
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